The full fixture list for the 2022/23 Premier League 2 and Premier League International Cup season have now been released.
Andrew Crofts's Under-21s kick-off their campaign with a trip to Crystal Palace on Monday 8 August.
The full list of fixtures can be found below.
| Opponent | Home/away | Date and kick-off |
| Crystal Palace (PL2) | Away | Monday 8 August 2022 - 19:00 |
| Liverpool (PL2) | Home | Sunday 14 August 2022 - 15:00 |
| Wolverhampton Wanderers (PL2) | Away | Monday 22 August 2022 - 19:00 |
| Arsenal (PL2) | Home | Friday 26 August 2022 - 19:00 |
| Leicester City (PL2) | Away | Saturday 3 September 2022 - 13:00 |
| Colchester United (Papa John's Trophy) | Away | Tuesday 6 September 2022 - 19:45 |
| Manchester City (PL2) | Home | Saturday 10 September 2022 - 15:00 |
| Everton (PL2) | Away | Sunday 18 September 2022 - 12:00 |
| Tottenham Hotspur (PL2) | Home | Friday 30 September 2022 - 19:00 |
| Gillingham (PJT) | Away | Tuesday 4 October 2022 - 19:00 |
| Manchester United (PL2) | Away | Saturday 8 October 2022 - 13:00 |
| Fulham (PL2) | Away | Friday 14 October 2022 - 14:00 |
| West Ham United (PL2) | Home | Saturday 22 October 2022 - 16:00 |
| Chelsea (PL2) | Home | Sunday 30 October 2022 - 16:00 |
| Charlton Athletic (PJT) | Away | Wednesday 2 November 2022 - 19:00 |
| Blackburn Rovers (PL2 | Away | Sunday 6 November 2022 - 13:00 |
| Crystal Palace (PL2) | Home | Monday 9 January 2023 - 19:00 |
| Manchester City (PL2) | Away | Sunday 15 January 2023 - 14:00 |
| Everton (PL2) | Home | Monday 23 January 2023 - 19:00 |
| Leicester City (PL2) | Home | Monday 30 January 2023 - 19:00 |
| Tottenham Hotspur (PL2) | Away | Monday 13 February 2023 - 19:00 |
| Blackburn Rovers (PL2) | Home | Monday 20 February 2023 - 19:00 |
| West Ham United (PL2) | Away | Monday 27 February 2023 - 19:00 |
| Wolverhampton Wanderers (PL2) | Home | Monday 6 March 2023 - 19:00 |
| Fulham (PL2) | Home | Monday 20 March 2023 - 19:00 |
| Liverpool (PL2) | Away | Monday 3 April 2023 - 14:00 |
| Arsenal (PL2) | Away | Friday 14 April 2023 - 19:00 |
| Manchester United (PL2) | Home | Sunday 23 April 2023 - 16:00 |
| Chelsea (PL2) | Away | Friday 28 April 2023 - 19:00 |