Defender Danique Kerkdijk is leaving the club when her contract expires at the end of June to join Dutch club FC Twente.
Kerkdijk joined Albion in 2019 from Bristol City and went on to make 56 WSL appearances to help establish the club in the Women’s Super League.
The 26-year-old is returning to Twente for a second spell, having played there between 2013-17.
Head coach Hope Powell said, “We’re really sorry to be losing Danique but totally understand that she wants a fresh challenge at a club she knows well.
“It has been hard for all our overseas players during the pandemic not being able to spend more time with their families. Danique has always been a brilliant professional on and off the field and everyone around the club will miss her.
“We wish her all the best for the next stage of her career. She knows she will always be welcome back at Brighton.”