Graham Potter’s men will be looking to get back on track after Saturday’s defeat to Manchester City, knowing that a win could secure Premier League safety depending on other results in the midweek round of fixtures.
Albion last made the trip along the south coast to St Mary’s back in September 2018.
Goals from Pierre-Emile Hojberg and Danny Ings fired the hosts into a two-goal lead, but Shane Duffy halved the deficit before Glenn Murray struck from the penalty spot in injury time to earn the Seagulls a share of the spoils.
The boss confirmed on Tuesday afternoon that Steven Alzate will be going in for surgery on his groin injury and will miss this week’s game along the south coast.
Apart from the young midfielder and fellow Colombian international Jose Izquierdo, who is recovering from knee surgery, Albion have a fit squad to select from.
Potter said, "Steven Alzate will go in for some surgery and Jose Izquierdo long-term is still missing.
"Aside from that, we have no new problems to report and everyone else is fully fit and ready to go."
Thursday night’s hosts will be without Sofiane Boufal, Yan Valery, Nathan Tella and Moussa Djenepo, with all four out with long-term injuries.
With another game against local rivals Bournemouth to come on Saturday, Saints manager Ralph Hasenhuttl has hinted that he may freshen up his squad against Albion after they drew 2-2 at Manchester United on Monday.
Our last fixture…
Manchester City 5
Sterling (21, 53, 81)
Albion line-up: Ryan (GK); Montoya (Lamptey 59), Dunk, Webster, Bernardo; Propper (Stephens 59), Bissouma, Gross (Burn 78), Mooy, Trossard (Jahanbakhsh 70); Connolly (Maupay 59).
Subs not used: Button (GK), Duffy, Mac Allister, Murray.
Their last fixture…
Manchester Utd 2
Southampton line-up: McCarthy; Walker-Peters, Stephens, Bednarek, Bertrand; Romeu (Obafemi 87), Ward-Prowse (Smallbone 69), Armstrong; Redmond, Ings, Adams (Long 64).
Subs not used: Gunn, Vestergaard, Vokins, Danso, Hojbjerg, Ferry.
The Southampton player to watch…
Danny Ings has notched 22 times in all competitions for Ralph Hasenhuttl’s men and is in contention to win the Golden Boot.
The English striker has netted 19 Premier League goals – only Leicester’s Jamie Vardy and Pierre-Emerick Aubameyang of Arsenal have scored more.
Ings made a season-long loan switch from Liverpool in the summer of 2018 and scored eight times last season. The move became permanent last July for a fee of £20million and since then Ings hasn’t looked back.
Referee: Andre Marriner. Assistants: Sian Massey-Ellis, Neil Davies. Fourth official: John Brooks. Replacement official: Timothy Wood.
VAR: Andy Madley. Assistant VAR: Peter Kirkup.